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ทำความรู้จัก Definisse Revitalise ไหมกระตุ้นคอลลาเจน P(LA+CL) คืออะไร? กระตุ้นคอลลาเจนแม่นยำ นาน 18 เดือน

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Definisse Revitalise Guide: What is P(LA-CL) Solid Biostimulator? Precision Collagen Boosting Lasting 18 Months

Dr. Sukunyarat Ramakun (Dr. Puii)
Dr. Sukunyarat Ramakun (Dr. Puii)
August 20, 2026 · Reading time 8 minutes

Discover Definisse Revitalise Program: P(LA+CL) Collagen-Stimulating Threads for Precise, Long-Lasting Results Up to 18 Months

As we age, skin laxity, wrinkles, and concerns in specific areas such as nasolabial folds, marionette lines, or a less-defined jawline often become more noticeable due to the gradual loss of collagen and elastin in the skin.

Many people want to restore firmer, more youthful-looking skin, but may still have concerns such as “Will it hurt? Will it cause lumps or fibrosis? Will any material remain in the skin?”

Today, we’ll introduce you to Definisse Revitalise Program, an innovative approach designed for those seeking natural-looking skin rejuvenation and highly precise collagen stimulation.

What is the Definisse Revitalise Program?

Definisse Revitalise Program is a Solid High-Precision Biostimulator in the form of fine threads, designed to stimulate new collagen production and provide precise structural support to targeted areas of the skin. It allows physicians to place the threads directly in specific areas that require treatment.

Combining the Power of Two Collagen Biostimulators with P(LA+CL) Technology

P(LA+CL) innovation combines two key collagen-stimulating components:

  1. PLLA (Poly-L-Lactic Acid): A widely used collagen biostimulator that helps stimulate fibroblasts to continuously produce collagen and hyaluronic acid, while offering high flexibility.

  2. PCL (Polycaprolactone): Provides strength and structural stability, with gradual biodegradation that helps support longer-lasting collagen stimulation.

When these two components work together through a Synergistic Effect, they promote a continuous regenerative process beneath the skin through Sustained Bio-Stimulation.

Will It Fully Biodegrade?

  • P(LA+CL) is fully biodegradable and naturally integrates with the skin.

  • Collagen-stimulating results can last up to 18 months.

4 Common Concerns About the Procedure

1. Worried About Fibrosis Under the Skin?

In an undesirable context, “fibrosis” refers to the abnormal formation of dense, hardened collagen tissue. However, the P(LA+CL) material used in Definisse Revitalise combines both strength and flexibility. It is designed to stimulate new collagen production in a controlled manner, gradually biodegrade, and naturally integrate with the skin. Therefore, it does not cause hard, lump-like fibrosis.

2. Worried About Residual Material or Incomplete Biodegradation?

P(LA+CL) is 100% biodegradable. Over time, the body breaks down the material through hydrolysis into lactic acid and 6-hydroxycaproic acid, which can then be naturally eliminated by the body, leaving no residual material behind.

3. Worried About Pain or a Long Recovery Time?

Definisse Revitalise uses ultra-fine 50 mm threads, and the procedure takes only 15–20 minutes. Discomfort during the procedure is minimal, with less pain and no fluid-related raised bumps or swelling. No downtime is required, allowing you to return to your daily activities immediately.

4. Is It Safe to Have an MRI After the Procedure?

Yes. MRI examinations can be performed safely because P(LA+CL) contains no metal components, unlike traditional gold threads. Therefore, it does not interfere with the magnetic fields used during an MRI scan.

Comparison : Definisse Revitalise Program (Solid) VS Liquid Biostimulator Program

Who Is the Definisse Revitalise Program Suitable For?

Suitable For:

  • Those with localized skin laxity who prefer not to receive injectable liquid collagen biostimulators.

  • Those who want to target specific areas, such as nasolabial folds, marionette lines, the jawline, or double chin.

  • Those who prefer to use only the amount needed for their specific skin concerns, without having to purchase an entire vial.

  • Those who have previously undergone skin-lifting treatments such as Ulthera or Thermage and want to maintain and further enhance skin firmness.

5 Most Popular Treatment Areas for the Definisse Revitalise Program

  1. Cheekbones / Mid-Cheek

  2. Hollow Cheeks

  3. Jowls

  4. Nasolabial Folds / Marionette Lines

  5. Double Chin & Jawline

Aftercare for the Definisse Revitalise Program

  1. 24 Hours: Avoid applying makeup to help reduce the risk of infection.

  2. 1–2 Weeks: Avoid saunas, hot baths or onsen, and excessive facial movements.

  3. 10 Days: Avoid facial treatments and vigorous facial massage.

  4. General Symptoms: If mild discomfort occurs, you may take paracetamol (acetaminophen) or apply a cold compress to help reduce swelling and bruising.

Why Choose the Definisse Revitalise Program at Reva Clinic?

1. Personalized Assessment & Facial Design for Every Case (Customized Facial Design)

Because facial structure, skin concerns, and skin thickness vary from person to person, physicians at Reva Clinic carefully assess each patient’s concerns and goals before the procedure. This allows for Precision Placement of the threads in targeted areas for a treatment plan tailored to each individual’s needs.

2. Use Only What You Need, Precisely Where You Need It

At Reva Clinic, treatment is tailored to each patient’s actual concerns. You can target only the areas that need treatment without having to purchase an entire vial or package, making it easier to manage your budget while receiving treatment suited to your needs.

3. Attentive Care at Every Step with a Gentle Technique and Minimal Discomfort

Our physicians have extensive knowledge of Facial Anatomy, allowing for precise and gentle placement of collagen biostimulators within the appropriate skin layers. This approach helps minimize bruising and swelling while keeping patients comfortable throughout the procedure.

4. Authentic Products Supplied Directly by the Official Distributor

Reva Clinic uses authentic Definisse Revitalise Program products supplied directly by the authorized distributor. The product can be verified before every procedure, providing greater confidence in its authenticity, quality, and safety.



Not sure what kind of care your skin needs?

Consult a dermatologist at Reva Clinic. We’re here to provide personalized guidance, helping you understand your skin and care for it with confidence.

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