Program Rh Collagen (Recombinant Human Collagen) for Skin Rejuvenation and Fine Lines

Thin, crepey, and less firm skin—even after previous aesthetic treatments?

As we age, our skin undergoes more than just sagging. Changes also occur within the skin's structure, including a reduction in collagen, elasticity, and moisture-retaining ability.

This means that not every case of crepey or aging skin can be addressed through lifting treatments or dermal fillers alone.

At Reva Clinic, Program Rh Collagen uses Karisma, a formulation combining Recombinant Human Collagen, Hyaluronic Acid (HA), and Carboxymethylcellulose (CMC). It is designed to support skin quality, structural integrity, and the skin's natural collagen production processes.

Our doctors assess the underlying causes of skin concerns before developing a personalized treatment plan.

What Is Rh Collagen Program?

Rh Collagen stands for Recombinant Human Collagen, a type of collagen produced through biotechnology using genetic sequences based on human collagen, rather than being directly extracted from animal skin or tissue.

The product used in this program is classified as a soft filler, formulated to provide some filling effects while supporting overall skin quality.

Unlike conventional dermal fillers, Program Rh Collagen is not primarily intended to add facial volume or reshape facial contours. Instead, it focuses on addressing age-related changes in skin structure and quality.

What Are the Key Ingredients in Rh Collagen Program?

1. Recombinant Human Collagen — Supports Collagen Production

Recombinant Human Collagen is associated with the production of Type I Collagen, the predominant collagen type found in the dermis.

Laboratory studies involving fibroblasts have shown increased Type I Collagen production and secretion following exposure to the product. However, these findings cannot be directly translated into a specific percentage increase in collagen within human skin.

2. Hyaluronic Acid (HA) — Supports Skin Hydration

Hyaluronic Acid helps retain moisture and maintain a hydrated skin environment that supports normal cellular function.

3. Carboxymethylcellulose (CMC) — Supports the Product's Structure

CMC contributes to the physical properties of the formulation. Mechanistic research has also explored its potential role in HA retention and changes within the extracellular matrix.

These three ingredients work together, although current evidence cannot determine which contributes most significantly to clinical outcomes.

How Is Rh Collagen Program Different from Other Injectable Collagen Treatments?

The key feature of Program Rh Collagen at Reva Clinic is its use of Recombinant Human Collagen, produced through genetic engineering rather than direct extraction from animal tissues such as bovine or porcine sources.

The collagen is produced using genetically modified silkworm technology and is based on human collagen protein sequences. This manufacturing approach is designed to reduce potential immune reactions, although allergic reactions remain possible.

The formulation combines three key ingredients:

• Rh Collagen: Associated with Type I Collagen production, supported by laboratory findings involving fibroblasts.

• Hyaluronic Acid (HA): Helps retain moisture and maintain skin hydration.

• Carboxymethylcellulose (CMC): Has mechanistic evidence relating to HA and collagen degradation processes.

Together, these ingredients are intended to support both the physical appearance and structural quality of aging skin.

However, there is currently insufficient direct comparative evidence to conclude that Rh Collagen is superior to every other injectable collagen treatment.

What Skin Concerns Can Rh Collagen Program Address?

Thin, Crepey, and Aging Skin

As collagen levels decline with age, the skin may become thinner, less firm, and more prone to fine wrinkles.

Program Rh Collagen focuses on supporting skin quality and structural changes associated with aging.

Fine Lines and Uneven Skin Texture

The treatment may help improve the appearance of fine lines and skin smoothness, particularly when these concerns are associated with thinning skin and reduced skin quality.

Deep folds caused by significant volume loss or skin laxity may require additional treatments.

Dehydrated Skin and Reduced Elasticity

Hyaluronic Acid helps retain moisture, while Rh Collagen is associated with skin structure and fibroblast activity.

Together, these ingredients may help the skin appear more hydrated, supple, and smooth. However, clinical outcomes vary, and further studies are needed.

Crepey Skin and Neck Wrinkles

The skin around the neck may become thinner and develop fine wrinkles with age.

Program Rh Collagen may be considered for improving the appearance of skin texture and fine lines in suitable treatment areas.

Deep neck folds or significant laxity may require other treatment approaches.

Under-Eye Crepiness and Fine Lines

The under-eye area has relatively thin skin, making fine lines and crepiness more noticeable.

Although skin-quality treatments may be relevant to these concerns, the periorbital area is listed as a prohibited injection site in the product documentation reviewed. Program Rh Collagen should not be presented as an injectable treatment for this area.

Other suitable treatment options can be discussed following medical assessment.

Mild Acne Scars and Uneven Skin Texture

Certain acne scars result from collagen loss within the dermis.

Program Rh Collagen may be considered as an adjunctive skin-quality treatment where permitted by the product's approved indications.

However, evidence supporting its direct effectiveness for correcting acne scars remains limited.

Deep or tethered acne scars may require targeted treatments such as subcision or laser procedures.

Thin, Crepey Skin on the Hands

As we age, the skin on the back of the hands may become thinner and lose elasticity, making veins and tendons more visible.

Skin-quality treatments may help address fine wrinkles and crepiness, although suitability for Program Rh Collagen depends on the product's approved indications.

Significant volume loss may be better addressed with other volume-restoring treatments.

Who Is a Suitable Candidate for Rh Collagen Program?

Program Rh Collagen may be considered for individuals who:

• Are approximately 40–70 years old and experience thin, crepey, or less firm skin.

• Have undergone skin-lifting treatments but still notice fine wrinkles or uneven skin texture.

• Have previously received collagen biostimulators but remain dissatisfied with their skin quality.

• Experience fine lines, dryness, or reduced skin elasticity.

• Prefer skin-quality improvement rather than additional facial volume from dermal fillers.

• Want a treatment approach focused on collagen-related skin changes and natural-looking results.

Crepey skin is not always caused by sagging alone. Changes in the skin's collagen structure may also contribute to its appearance.

Where Can Rh Collagen Program Be Injected?

Program Rh Collagen focuses on improving skin quality. Depending on the product's approved indications and the doctor's assessment, treatment may be considered for selected areas with concerns such as:

• Forehead: Fine lines and uneven skin texture.

• Under-eye area: Thin, crepey skin and fine wrinkles.

• Nasolabial folds: Wrinkles and reduced skin elasticity around the cheeks.

• Acne scars: Depressed scars and uneven cheek texture.

• Marionette lines: Age-related wrinkles around the corners of the mouth.

• Perioral area: Fine lines around the lips.

• Neck: Thin, crepey skin and fine wrinkles.

• Back of the hands: Thin, dry skin with age-related wrinkles.

Important: This list describes skin concerns and areas for medical assessment, not a list of approved injection sites. The reviewed product documentation prohibits injections in the periorbital area and glabella. All treatment locations must comply with the product's approved indications in Thailand.

How Much Rh Collagen Program Is Needed, and How Many Sessions Are Recommended?

The amount of Program Rh Collagen required varies according to age, skin condition, degree of crepiness, and treatment area.

How Many Sessions Are Recommended?

The Karisma treatment protocol generally recommends two initial sessions, approximately one month apart, to support ongoing skin-quality improvement.

• Session 1: Initial treatment to address skin quality.

• Session 2: Follow-up treatment approximately 30 days later.

• Maintenance: Additional treatment may be considered around the fourth month, depending on the skin's response and the doctor's assessment.

How Many Boxes Are Needed per Session?

Each box of Karisma contains 2 mL of product.

A protocol using 2 mL per session corresponds to one box per treatment, or two boxes across the initial two-session course.

However, individuals with more extensive skin concerns or multiple treatment areas may require an individualized assessment.

At Reva Clinic, our doctors evaluate skin density, wrinkle severity, and treatment areas before recommending the appropriate amount and number of sessions.

When Will I See Results, and How Long Do They Last?

Results following Program Rh Collagen can be divided into two phases:

• Early results: The skin may appear plumper and more hydrated due to the CMC gel and HA components. This initial plumping effect may last approximately 2–3 months, although the duration has not been definitively established for every individual.

• Long-term results: Changes in skin quality associated with collagen production develop gradually over several weeks to months. The treatment material describes an estimated duration of 6–12 months after the final session, although further clinical evidence is needed to establish the duration reliably.

Results vary depending on age, baseline skin condition, and individual response to treatment.

Is There Any Downtime After Rh Collagen Injections?

Temporary reactions following treatment may include:

• Swelling, redness, or tenderness at the injection sites.

• Bruising caused by needle insertion.

• Temporary bumps or unevenness.

• Localized skin irritation.

Recovery time varies depending on the injection technique, treatment area, and individual response.

Contraindications and Precautions

Program Rh Collagen is not suitable for individuals with the following conditions:

• Known allergies to any ingredients in the product.

• Autoimmune connective tissue diseases.

• Uncontrolled epilepsy.

• A tendency to develop hypertrophic scars.

• Active skin infections or inflammation at the intended injection site.

• Age under 18 years.

• Pregnancy or breastfeeding, for which treatment is not recommended.

The product documentation also prohibits injections into the periorbital area and glabella.

Before treatment, patients should inform their doctor about medical conditions, allergies, medications, and previous aesthetic procedures.

Although the product contains Recombinant Human Collagen, allergic reactions and injection-related complications remain possible.

Before and Aftercare for Rh Collagen Program

Before Treatment

• Inform your doctor about medical conditions, allergies, medications, supplements, and previous aesthetic treatments.

• Avoid alcohol for 24 hours before treatment to help reduce the risk of bruising.

• Discuss medications and supplements that may increase bruising, such as aspirin, NSAIDs, or fish oil. Do not stop prescribed medication without medical advice.

• Postpone treatment if there is an active skin infection or inflammation in the treatment area.

• Inform your doctor if you have recently undergone laser treatments or chemical peels.

After Treatment

• Mild swelling, redness, or bruising may occur and usually improves within a few days.

• Avoid pressing, rubbing, or massaging the treated area unless instructed by your doctor.

• Avoid strenuous exercise, saunas, and excessive heat for approximately 24–48 hours.

• Avoid heat-based lifting treatments, such as Program Ulthera or Oligio X, in the treated area for at least two weeks or as advised by your doctor.

• Avoid irritating exfoliating products until the skin has recovered.

• Apply moisturizer and sunscreen regularly.

• Seek immediate medical attention if you experience severe pain, unusual skin discoloration, or changes in vision.

Treatment Process at Reva Clinic

Step 1 — Skin Assessment

Our doctors evaluate skin quality, elasticity, wrinkles, laxity, and facial structure to identify the underlying causes of skin concerns and determine an appropriate treatment approach.

Step 2 — Personalized Treatment Planning

A customized treatment plan is developed based on the patient's skin concerns, treatment areas, product amount, and previous aesthetic procedures.

Step 3 — Authenticity Verification

Before treatment, patients can inspect the product packaging, batch number, expiration date, and relevant authenticity information to help ensure product traceability.

Step 4 — Treatment

The skin is cleansed and prepared before injection.

Depending on the skin condition, treatment area, and individual needs, the doctor selects an appropriate injection technique using either a sharp needle or a blunt-tip cannula, in accordance with the product's instructions for use.

Step 5 — Follow-up

A follow-up assessment is typically scheduled approximately one month after treatment to evaluate changes in skin quality and determine whether additional sessions or complementary treatments are appropriate.

Program Rh Collagen vs. Program HA Filler: What's the Difference?

Although both are injectable treatments, they serve different purposes.

Program Rh Collagen focuses on improving the appearance of thin, crepey skin and supporting skin quality through a combination of Rh Collagen, HA, and CMC.

Program HA Filler primarily restores lost facial volume, making it suitable for concerns such as hollow cheeks, deep folds, and age-related facial volume loss.

In summary: Rh Collagen focuses on skin quality and subtle plumping, while HA Filler is generally more suitable for volume restoration and facial contouring.

Read more: Program Filler

Program Rh Collagen vs. Program Sculptra: What's the Difference?

Both treatments are associated with collagen-related skin improvement, but their ingredients and mechanisms differ.

Program Rh Collagen combines Recombinant Human Collagen, HA, and CMC to support skin quality and provide some initial plumping effects.

Program Sculptra contains Poly-L-Lactic Acid (PLLA), a collagen biostimulator designed to stimulate gradual collagen production and address age-related changes in skin firmness and facial volume.

In summary: Rh Collagen focuses on skin quality and plumping, while Sculptra emphasizes collagen stimulation for structural and volume-related improvements.

Read more: Program Sculptra

Can I Get Rh Collagen If I Didn't See Results from Sculptra?

If you have previously received Sculptra but still experience thin, crepey skin or fine wrinkles, your concerns may involve more than facial volume loss.

Age-related changes in skin quality may also contribute to the appearance of wrinkles and uneven texture.

Program Rh Collagen may be considered as another skin-quality treatment option following a medical assessment.

However, there is currently insufficient evidence to conclude that Rh Collagen can directly correct a lack of response to Sculptra.

Program Rh Collagen vs. Program Definisse Revitalise Threads

Both treatments focus on skin quality, but they work differently.

Program Rh Collagen combines Rh Collagen, HA, and CMC to address thin, crepey skin and provide subtle plumping effects.

Program Definisse Revitalise Threads uses absorbable threads that stimulate collagen formation around the threads. It may be considered for targeted improvements in skin firmness and tightness, such as around the jawline, nasolabial folds, or marionette lines.

Unlike conventional volumizing fillers, these threads are not primarily intended to add facial volume.

In summary: Rh Collagen focuses on skin quality and plumping, while Definisse Revitalise Threads may be considered for localized improvements in skin firmness.

Read more: Program Definisse Revitalise

Program Rh Collagen vs. Program ICONIC SKIN

Both programs focus on skin quality, but their treatment goals differ.

Program Rh Collagen is designed for individuals concerned about thin, crepey skin, fine wrinkles, and age-related changes in skin structure.

Program ICONIC SKIN, also known as Reva's Celebrity Skin Program, focuses on improving hydration, radiance, smoothness, and an overall healthy-looking glow.

ICONIC SKIN offers different formulations based on individual skin concerns and treatment goals.

In summary: Rh Collagen may be considered for age-related skin-quality concerns, while ICONIC SKIN focuses more on hydration, radiance, and glowing skin.

Read more: Program ICONIC SKIN

At Reva Clinic, our doctors assess whether a patient's main concern is related to thinning skin, facial volume loss, or skin laxity before recommending an appropriate treatment.

Why Choose Program Rh Collagen at Reva Clinic?

At Reva Aesthetic Clinic, we believe that not all crepey or aging skin has the same underlying cause.

Some patients experience thinning of the dermis, while others may have skin laxity, facial fat loss, or structural changes occurring together.

Our doctors prioritize identifying the underlying concerns before recommending aesthetic procedures.

Every treatment plan is personalized according to the patient's skin condition, previous treatments, and expectations.

Consult our doctors at Reva Aesthetic Clinic for a personalized skin assessment and Program Rh Collagen treatment plan.

Treatment outcomes, recovery, and duration of results vary between individuals. A medical consultation is recommended before undergoing treatment.