In recent years, Polynucleotide (PN) has become one of the most popular skin rejuvenation treatments in aesthetic medicine. As the field of regenerative aesthetics continues to evolve, a variety of PN-based products have been developed to address different skin concerns.
In South Korea and many Asian countries, Program Rejuran HB Plus and Vitaran I are two of the most widely recognized Polynucleotide treatments. While both are formulated with Polynucleotide (PN) as their key active ingredient, they differ in formulation, characteristics, and clinical indications.
Although many people assume these treatments deliver similar results, each has its own unique strengths and may be better suited to different skin conditions and treatment goals.
Program Rejuran HB Plus and Vitaran I share several key characteristics:
Both are Polynucleotide (PN) skin rejuvenation treatments
Both use Polynucleotide as the primary active ingredient
Both focus on supporting the skin's natural repair and regeneration rather than adding facial volume like dermal fillers
Both treatments are commonly used to improve overall skin quality, reduce fine lines, and rejuvenate aging or damaged skin.
Although both belong to the Polynucleotide family, they differ in several important aspects, including:
Product formulation
Viscosity and texture
The addition of Hyaluronic Acid (HA) and Lidocaine
Recommended treatment areas
Comfort during injection
Their unique clinical strengths and treatment outcomes
In this article, we provide a comprehensive comparison of Program Rejuran HB Plus and Vitaran I, including:
Product composition
Mechanism of action
Key advantages and limitations
Recommended treatment areas
Expected clinical outcomes
Which treatment may be more suitable for different skin concerns
Our goal is to help you understand the differences between these two Polynucleotide treatments and choose the option that best matches your skin condition and aesthetic goals.
Although Program Rejuran HB Plus and Program Vitaran I both belong to the Polynucleotide (PN) category, they are not simply the same product marketed under different brand names.
Each product has been developed with its own formulation and physical properties, making it suitable for different skin conditions and treatment areas.
In other words, while both use the same core active ingredient, the differences in their formulations influence both the treatment experience and their clinical applications.
Program Rejuran HB Plus combines Polynucleotide (PN), Hyaluronic Acid (HA), and Lidocaine in a single formulation. Hyaluronic Acid helps improve skin hydration, while Lidocaine reduces discomfort during the injection procedure.
In contrast, Program Vitaran I is a Polynucleotide-based product that does not contain Hyaluronic Acid or Lidocaine. Instead, it is specifically formulated for delicate skin, particularly the under-eye area, with a formulation designed to minimize discomfort and post-injection swelling in these sensitive regions.
The addition of Hyaluronic Acid (HA) in Program Rejuran HB Plus provides an immediate boost in skin hydration, giving the skin a plumper and more radiant appearance shortly after treatment, while the regenerative effects of Polynucleotide continue to develop over time.
Lidocaine is a local anesthetic that helps reduce discomfort during the injection process, making the treatment more comfortable—especially for patients who are concerned about pain.
However, the presence or absence of HA and Lidocaine does not necessarily mean that one treatment delivers superior skin rejuvenation results. Rather, these differences reflect each product's formulation design and contribute to a different treatment experience.
Both Program Rejuran HB Plus and Program Vitaran I use Polynucleotide (PN) as the core ingredient for skin regeneration, but they are designed with different treatment philosophies.
Program Rejuran HB Plus focuses on skin rejuvenation while providing additional hydration and a more comfortable injection experience through the inclusion of Hyaluronic Acid and Lidocaine.
Program Vitaran I is specifically formulated for delicate skin, particularly the under-eye area, with a product design intended to optimize treatment in these sensitive regions.
Both Program Rejuran HB Plus and Program Vitaran I are Polynucleotide (PN)-based treatments. However, their formulations are designed differently, which means they may be suitable for different skin conditions and treatment goals.
The choice of treatment should therefore be based on a doctor’s assessment, taking into consideration the individual’s skin concerns, treatment area, and expected outcomes.
A doctor may consider Program Rejuran HB Plus for individuals with skin concerns or treatment goals such as:
Dry or dehydrated skin
Dryness around the eyes or makeup settling into fine lines
A desire for plumper, more hydrated-looking skin due to the Hyaluronic Acid (HA) contained in the formulation
Concerns about discomfort during treatment, as the product contains Lidocaine
Previous discomfort with other Polynucleotide injections and a preference for a formulation designed to provide greater comfort during treatment
A doctor may consider Program Vitaran I for individuals who:
Want to improve overall skin quality
Have delicate or sensitive skin, particularly around the eye area
Are interested in Polynucleotide treatment but do not primarily aim to increase skin hydration
Prefer an option with a lower starting cost, depending on the pricing set by each medical facility
Both Program Rejuran HB Plus and Program Vitaran I have their own distinct characteristics and advantages. There is no single treatment that is suitable for everyone.
The choice of program should take into consideration:
Skin condition
Treatment area
Treatment goals
Budget
A doctor’s assessment and recommendations
These factors help determine the most appropriate treatment approach for each individual.
Note: Treatment results may vary between individuals. A consultation and assessment by a qualified doctor are important for developing an appropriate and personalized treatment plan.
Although Program Rejuran HB Plus and Program Vitaran I are both Polynucleotide (PN)-based treatments, there is no single program that is ideal for everyone.
At Reva Aesthetic Clinic, we believe that successful treatment begins with a thorough assessment of each patient's skin condition, treatment goals, and areas of concern. These factors help guide the selection of the most appropriate program, injection technique, and personalized treatment plan.
Our physicians practice Evidence-Based Medicine and continuously update their knowledge through scientific conferences, medical training, and educational programs in both Thailand and abroad. This ongoing commitment allows us to incorporate the latest clinical evidence and treatment techniques into patient care.
We believe that choosing the right treatment for an individual's skin is more important than choosing a product based solely on its brand name.
Both Program Rejuran HB Plus and Program Vitaran I are Polynucleotide (PN)-based skin rejuvenation treatments.
Both programs utilize Polynucleotide (PN) as their key active ingredient but differ in formulation and product characteristics.
Program Rejuran HB Plus contains Hyaluronic Acid (HA) and Lidocaine.
Program Vitaran I is formulated for delicate skin, particularly the under-eye area.
The choice of treatment should be based on the patient's skin condition, treatment goals, and a physician's clinical assessment.
At Reva Aesthetic Clinic, our physicians provide a personalized skin assessment and recommend the most appropriate treatment based on your skin condition, treatment goals, and individual needs. Every treatment plan is tailored according to current medical evidence and clinical judgment to help achieve natural-looking and appropriate outcomes.
Have you ever wondered why some people look naturally radiant, smooth, and glowing even without using beauty filters? The secret of Glass Skin is not having the fairest complexion or completely poreless skin. Instead, it is about healthy-looking skin that appears hydrated, smooth, even-toned, and naturally luminous.
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Consult a dermatologist at Reva Clinic. We’re here to provide personalized guidance, helping you understand your skin and care for it with confidence.
